Studies on 1,3-benzoxazines. VI. Formation of quinazolines and 4H-3,1-benzoxazines by the reaction of 4-chloro-2H-1,3-benzoxazines with aminoacetophenone, aminobenzophenone and aminobenzyl alcohol derivatives.
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چکیده
منابع مشابه
Synthesis and biological studies of triazolo-/thiadiazolo-benzoxazines.
Diethyl bromomalonate (2) with an equimolar amount of 2-aminophenol (1) in the presence of sodium fluoride undergoes a cyclization reaction to form 2H,4H-2-ethoxycarbonyl-3,4-dihydro-3-oxo-1,4-benzoxazine (3). Furthermore, compound 3 undergoes a condensation reaction with hydrazine hydrate in the presence of methanol to yield 2H,4H-2-hydrazinocarbonyl-3,4-dihydro-3-oxo-1,4-benzoxazine (4), whic...
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ABSTRACT Benzoxazine and its derivatives are used in organic synthesis for building natural and designed synthetic compounds and they have been frequently utilized as suitable skeletons for the design of biologically active compound. This review covers updated information on the most active benzoxazine derivatives that have been reported to show considerable pharmacological actions such as anti...
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A series of new 2,3-disubstituted-3,4-dihydro-2H-1,3-benzoxazines were prepared in moderate to excellent yields by aza-acetalizations of aromatic aldehydes with 2-(N-substituted aminomethyl)phenols in the presence of TMSCl. Their structures were confirmed by IR, ¹H-NMR, ¹³C-NMR, MS and elemental analysis. The fungicidal activities of the target compounds were preliminarily evaluated, and some c...
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Four previously synthesized (R =-F,-F,-CI,-Br,-l) and one new (R=-H) 3,3' -ethylene-bis(3,4-dihydro-6R-2H-1,3-benzoxa2Íne) were preliminary tested for insecticidal activity against M. domestica (Díptera) and C. cary (Lepidoptera) larvae. Under laboratory conditions no toxic action was observed. All larvae continued development and pupated successfully but internal or external malformations were...
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3,4-dihydro-3-phenyl-2H-1,3-benzoxazines derived from phenol-, resorcinol-, and phloroglucinol give monomers with one, two, and three oxazine units at a single benzene ring, respectively. Aside from the synthesis and characterization of such multifunctional benzoxazines, reactivity and polymerization behavior is studied in dependence of the oxazine functionality. Monomer reactivities are direct...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1982
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.30.559